The tachykinin receptors
نویسندگان
چکیده
منابع مشابه
Targeting tachykinin receptors in neuroblastoma
Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%. Adding targeted drugs to first-line therapy regimens is a promising approach to improve survival in these patients. TACR1 activation by substance P has been reported to be mitogenic in cancer cell lines. Tac...
متن کاملTachykinin receptors and airway pathophysiology.
The mammalian tachykinins (TKs), substance P and neurokinin A, are present in sensory nerve fibres in the upper and lower airways of various mammalian species, including humans. TKs are released from these afferent nerves in an "efferent" mode at peripheral level, especially in response to irritant stimuli. TKs exert a variety of biological effects (bronchoconstriction, plasma protein extravasa...
متن کاملPharmacology and Function of Tachykinin Receptors
The existence of SP was described in the 1930s by Von Euler and Gaddum in mammals, and tachykinin peptides were identified and sequenced by Erspamer in non-vertebrated (eledoisin) and then in nonmammalian species (physalaemin). In the 1960s Lembeck continued Von Euler and Gaddum’s studies, describing the effects of SP and other tachykinins in the central nervous system (CNS) and peripheral prep...
متن کاملTachykinin receptors antagonism for asthma: a systematic review
BACKGROUND Tachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics. These neuropeptides act mainly by their receptors NK1, NK2 and NK3, respectively which may be targets for new asthma therapy. METHODS This review systematically examines randomized controlled trials evaluating ...
متن کاملThe tachykinin peptide family.
The tachykinin peptide family certainly represents one of the largest peptide families described in the animal organism. So far, more than 40 tachykinins have been isolated from invertebrate (insects, worms, and molluscs), protochordate, and vertebrate (skin, gastrointestinal tract, peripheral and central nervous system) tissues. Substance P (SP), first identified by bioassay as early as 1931 b...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1994
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(94)80082-0